EGG DONATION
If the problem is originated from the woman and her eggs are not in good quality and quantity in the couples that can’t have baby, oocyte donation (egg donation) is used for getting pregnant.
The general success rate is more than 80% in IVF cycles with egg donation. So every woman can get her baby in every age.
To whom egg donation is performed?
-to women who has a uterus but undergoing pre-menopause
-to women who are undergoing menopause
-to women that their ovaries are taken out for any reason
-to women whose ovaries lost their activity because taking radiotherapy or chemotherapy
-to women whose eggs are low in quantity and quality
-to women who had recurrent miscarriages
-to women who has genetic disorders that can be inherited to their babies…
How to use egg donor for egg donation?
After deciding that egg donation is necessary for the patient couple, the donor is selected from the donor list of the center that consists of the women who applied for sharing their eggs. While selecting the suitable donor it is necessary to be careful about the physical properties of the couple.
After selecting the donor, menstrual periods of both donor and mother candidate is programmed to be gone together. And the eggs are induced in a donor, while the uterus is prepared in mother candidate and after collecting eggs from a donor and fertilized with father candidates sperms the embryos are transferred on day 3 or 5 of their growing. And the couple starts for waiting for a pregnancy test on 12th day after transfer.
The Requirements for Egg Donors:
1- the age of egg donor must be 20-35
2- donor must be physically healthy
3- the body mass index must be 19-29
4- donor must be psychologically healthy
5- donor shouldn’t have drug dependent
6-donor shouldn’t have any inherited genetic disorder
7-donors ovaries both should be healthy
8-should have karyotype analysis result 46, XX
9-required genetic and laboratory test is performed (Anti-Hiv 1, 2, HbsAg, Anti HBc, Anti-HCV, Syphilis, and sometimes if required HTLV-1 RHD, CMV, T.cruzi, cystic fibrosis, thalassemia, …)
How Egg Donation is performed?
Egg donation consists of three stages;
1-Deciding that we have to use egg donation and making PRE-PREPARATION:
making required tests and getting reports for mother candidate (FSH, LH, Estradiol, Prolactin on day 2 or 3 of menstrual bleeding, AMH on any day) and be sure that egg donation is needed. After this, starting to use some medicine to woman partner to refresh and strengthen the uterus and to man partner for inducing the quality of sperms. The donor is selected and bleeding time programing is performed for donor and mother candidate to start bleeding on the same day. If the mother candidate is in menopause, bleeding is not required for her.
(This stage takes 1 week – 1 month and can be performed in patients’ country).
2-PREPARATION
On day 2 or 3 of bleeding (menstrual cycle, for both donor and mother candidate) in the month that couple decide to come for the treatment, making required extra tests to both women and start using some more medication like injections for inducing eggs in donor and some medicine for mother candidate for preparing the uterus for embryo. Generally, this medication stage takes 10 days. If the mother candidate is in menopause, bleeding is not required for her (this stage takes nearly ten days and can be performed in patients’ country). After 12 days (on 14. day of bleeding) couple must be in Cyprus for oocyte pick up (OPU, egg collecting).
3- OPERATION
This starts with oocyte pick up (egg collection) from the donor and ends with embryo transfer on day 3 or 5 of embryo development to the uterus of mother candidate. The eggs that are collected from donor woman are fertilized with the father candidate sperms on OPU Day (Day 0). After 3 or 5 days, embryos are transferred to the uterus of mother candidate. After transfer operation, couples can return to their countries whenever they want (this stage takes 3-5 days and patients must be in Cyprus). On 12th day after transfer beta-HCG test in the blood must be done for learning pregnancy is negative or positive.
SPERM DONATION
The couples who decide to perform sperm donation, a special medication protocol issued for increasing the number and the quality of the eggs of mother candidate.
After this, the eggs are collected and fertilized with donor sperm in laboratory conditions.
The embryos that are obtained are transferred to the uterus of mother
candidate and start waiting for pregnancy. And after 12 days pregnancy blood test has been made.
In the infertile couples, if the problem is raised from malefactors, if there is not any sperm in the ejaculate, sperms don’t have to fertilize property sperm donation can be used for having a baby.
The sperms that are being used for sperm donation are supplied from sperm banks. sperm donors are being checked about their health and physiological situation. And all rules that are necessary have to be performed during the selection of suitable sperms.
The rules are;
1- the age of sperm donor must be 20-45
2-the karyotype analysis result must be 46XY
3-physical and ethnical properties must be known
4-required genetic and laboratory test are performed (Blood Type, Thalassamia, Cystic fibrosis, SickleCell, Anti HIV1, and Anti HIV2, HBsAg, Anti HBc, Anti HCV, VDRL-RPR, HTLV-1/II Antibody, Chlamydia, Gonorrhea..)
To whom sperm donation is performed?
-to the men who have no sperm in their ejaculate
-to the men that have sperm cells but their cells have no fertilization capacity
-to the men that have genetic disorders that can be inherited to their babies
-to the men that there is no sperm in their TESA/TESE tissues
-to the women that want to be a mother without a partner
How to use sperm donor for sperm donation?
Firstly the sperm donors are checked for health situation for infectious and genetic disorders besides fertility capacity tests and then are stocked in the sperm banks. The sperms are selected from the bank lists according to patients’ choices with being careful about all physical properties to be suitable for especially dad candidate. After that, they are shipped in required conditions to centers and are used after thawing for sperm donation.
How sperm donation is performed?
Sperm donation consists of 3 stages;
1-Deciding that we have to use sperm donation and making PRE-PREPARATION:
making required tests and getting reports, (spermiogram, TESE /TESA Report, FSH, …) and be sure that sperm donation is needed. after this, starting to use some medicine to woman partner to refresh and strengthen the uterus and ovaries. (This stage takes 1 week – 1 month and can be performed in patients’ country)
2-PREPARATION
on day 2 or 3 of bleeding (menstrual cycle) in the month that couple decides to come for the treatment, making required tests to the woman and start using some more medication like injections for inducing eggs (this stage takes nearly ten days and can be performed in patients’ country). After 12 days (on 14. day of bleeding) couple must be in Cyprus for oocyte pick up (OPU, egg collecting).
3- OPERATION
this starts with oocyte pick up and ends with embryo transfer on day 3 or 5 of embryo development (this stage takes 3-5 days and patients must be in Cyprus). The eggs that are collected are fertilized with the bank sperm that was selected before by the couple or by the center on OPU Day (Day 0). After 3 or 5 days embryos are transferred to the uterus. After transfer couples can return to their countries whenever they want. On 12th day after transfer, a beta-HCG blood test must be done for learning pregnancy is negative or positive.
EMBRYO DONATION
If the problem is originated from both woman and man in the couple, and both of them are infertile and can’t have baby, embryo donation is used for getting pregnant.
The general success rate is more than 80% in IVF cycles with embryo donation.
So every woman and man can get their baby in every age and every condition.
To which couples embryo donation is performed?
-to women who have a uterus but undergoing pre-menopause
-to women who undergoing menopause
-to women that their ovaries are taken out for any reason
-to women whose ovaries lost their activity because taking radiotherapy or chemotherapy
-to women whose eggs are low in quantity and quality
-to women who have recurrent miscarriages
-to women who have genetic disorders that can be inherited to their babies
and when the partner (father candidate)
-have no sperm in their ejaculate
-have sperm cells but their cells have no fertilization capacity
-have genetic disorders that can be inherited to their babies
-that there is no sperm in their TESA/TESE tissues
How to use sperm and egg donors for donation (embryo donation)?
After deciding that embryo donation is necessary for the patient couple, the egg donor is selected from the donor list of the center that consists of the women who applied for sharing their eggs. While selecting the suitable donor it is necessary to be careful about physical and ethnical properties of the couple. And sperm donor is selected from accredited sperm banks according to family candidates properties and their special demands is well.
After selecting the donors, menstrual periods of both egg donor and mother candidate is programmed to be gone together and sperms are shipped from the banks to fertility centers. The eggs are induced in egg donor, while the uterus is prepared in mother candidate and after collecting eggs from the donor on egg collecting day they fertilized with sperms of the selected sperm donor, then the embryos are transferred on day 3 or 5 of their growing into the uterus of mother candidate. And couple starts for waiting for a pregnancy test on the 12th day after transfer.
The Requirements for Egg Donors:
1- the age of egg donor must be 20-35
2- donor must be physically healthy
3- the body mass index must be 19-29
4- donor must be psychologically healthy
5- donor shouldn’t have drug dependent
6-donor shouldn’t have any inherited genetic disorder
7-donors ovaries both should be healthy
8-should have karyotype analysis result in 46, XX
9-required genetic and laboratory test are performed (Anti-Hiv 1, 2, HbsAg, Anti HBc, Anti-HCV, Syphilis, and sometimes if required HTLV-1 RHD, CMV, T.cruzi, cystic fibrosis, thalassemia, …)
The Requirements of Sperm Donors:
1- the age of sperm donor must be 20-45
2-the karyotype analysis result must be 46XY
3-physical and ethnical properties must be known
4-required genetic and laboratory test are performed (Blood Type, Thalassamia, Cystic fibrosis, SickleCell, Anti HIV1, and Anti HIV2, HBsAg, Anti HBc, Anti HCV, VDRL-RPR, HTLV-1/II Antibody, Chlamydia, Gonorrhea..)
How both egg and sperm (Embryo) Donation is performed?
Embryo donation consists of three stages;
1-Deciding that we have to use embryo donation and making PRE-PREPARATION:
making required tests and getting reports for mother candidate (FSH, LH, Estradiol, Prolactin on day 2 or 3 of menstrual bleeding, AMH on any day) and be sure that egg donation is needed. Besides these, making required tests for father candidate and also decide that sperm donation is required (spermiogram, TESE/TESA Reports, FSH, LH, Testosterone). After this, starting to use some medicine to woman partner to refresh and strengthen the uterus. The donor is selected and bleeding time programing is performed for donor and mother candidate to start bleeding on the same day. If the mother candidate is in menopause, bleeding is not required for her. And during this time, selected sperms are shipped from the banks (This stage takes 1 week – 1 month and can be performed in patients’ country).
2-PREPARATION
on day 2 or 3 of bleeding (menstrual cycle, for both donor and mother candidate) in the month that couple decide to come for the treatment, making required extra tests to both women and start using some more medication like injections for inducing eggs in donor and some medicine for mother candidate for preparing the uterus for embryo. Generally, this medication stage takes 10 days. If the mother candidate is in menopause, bleeding is not required for her (this stage takes nearly ten days and can be performed in patients’ country). After 12 days (on 14. day of bleeding) couple must be in Cyprus for oocyte pick up (OPU, egg collecting). Then selected sperms are ready to use in the laboratory of the Center.
3- OPERATION
this starts with oocyte pick up (egg collection) from the egg donor and ends with embryo transfer on day 3 or 5 of embryo development to the uterus of mother candidate. Couples must be here on the egg collection day or one day before. The eggs that are collected from donor woman are fertilized with the donor sperms on OPU Day (Day 0). After 3 or 5 days, embryos are transferred to the uterus of mother candidate. After transfer operation, couples can return to their countries whenever they want (this stage takes 3-5 days and patients must be in Cyprus). On the 12th day after transfer, a beta-HCG blood test must be done for learning pregnancy is negative or positive.